Spinal injection of TNF-α-activated astrocytes produces persistent pain symptom mechanical allodynia by releasing monocyte chemoattractant protein-1.

Gao, Yong-Jing

Spinal injection of TNF-α-activated astrocytes produces persistent pain symptom mechanical allodynia by releasing monocyte chemoattractant protein-1. [electronic resource] - Glia Nov 2010 - 1871-80 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

1098-1136

10.1002/glia.21056 doi


Animals
Animals, Newborn
Antibodies--therapeutic use
Astrocytes--drug effects
Calcium-Binding Proteins--metabolism
Cells, Cultured
Cerebral Cortex--cytology
Chemokine CCL2--immunology
Disease Models, Animal
Enzyme Inhibitors--pharmacology
Enzyme-Linked Immunosorbent Assay--methods
Gene Expression Regulation--drug effects
Glial Fibrillary Acidic Protein--metabolism
Hyperalgesia--chemically induced
Injections, Spinal--methods
MAP Kinase Kinase 4--metabolism
Male
Mice
Mice, Knockout
Microfilament Proteins
Pain Threshold--drug effects
RNA, Small Interfering--therapeutic use
Receptors, Tumor Necrosis Factor--deficiency
Receptors, Tumor Necrosis Factor, Type I--deficiency
Spinal Cord--pathology
Tumor Necrosis Factor-alpha--adverse effects