Structure-function correlation of G6, a novel small molecule inhibitor of Jak2: indispensability of the stilbenoid core.

Majumder, Anurima

Structure-function correlation of G6, a novel small molecule inhibitor of Jak2: indispensability of the stilbenoid core. [electronic resource] - The Journal of biological chemistry Oct 2010 - 31399-407 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1083-351X

10.1074/jbc.M110.168211 doi


Amino Acid Substitution
Apoptosis--drug effects
Cell Line, Tumor
Cell Proliferation--drug effects
Drug Screening Assays, Antitumor
Humans
Janus Kinase 2--antagonists & inhibitors
Mutation, Missense
Polycythemia Vera--drug therapy
Protein Kinase Inhibitors--chemistry
STAT3 Transcription Factor--genetics
STAT5 Transcription Factor--genetics
Stilbenes--chemistry
Structure-Activity Relationship