Novel tricyclic pyrazole BRAF inhibitors with imidazole or furan central scaffolds.

Niculescu-Duvaz, Dan

Novel tricyclic pyrazole BRAF inhibitors with imidazole or furan central scaffolds. [electronic resource] - Bioorganic & medicinal chemistry Sep 2010 - 6934-52 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1464-3391

10.1016/j.bmc.2010.06.031 doi


Animals
Binding Sites
Computer Simulation
Female
Furans--chemistry
Humans
Imidazoles--chemistry
Mice
Mutation
Protein Kinase Inhibitors--chemical synthesis
Protein Structure, Tertiary
Proto-Oncogene Proteins B-raf--antagonists & inhibitors
Pyrazoles--chemical synthesis
Structure-Activity Relationship