A distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal.

Milyavsky, Michael

A distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal. [electronic resource] - Cell stem cell Aug 2010 - 186-97 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1875-9777

10.1016/j.stem.2010.05.016 doi


Adaptor Proteins, Signal Transducing--metabolism
Animals
Apoptosis--radiation effects
Apoptosis Regulatory Proteins--metabolism
Cell Lineage--radiation effects
Cell Proliferation--radiation effects
Cell Survival--radiation effects
Cytoprotection--radiation effects
DNA Breaks, Double-Stranded--radiation effects
DNA Damage
HeLa Cells
Hematopoietic Stem Cells--cytology
Humans
Mice
Myelopoiesis--radiation effects
Proto-Oncogene Proteins c-bcl-2--metabolism
Radiation, Ionizing
Recombination, Genetic--radiation effects
Tumor Suppressor Protein p53--metabolism