Curcumin stimulates reactive oxygen species production and potentiates apoptosis induction by the antitumor drugs arsenic trioxide and lonidamine in human myeloid leukemia cell lines.

Sánchez, Yolanda

Curcumin stimulates reactive oxygen species production and potentiates apoptosis induction by the antitumor drugs arsenic trioxide and lonidamine in human myeloid leukemia cell lines. [electronic resource] - The Journal of pharmacology and experimental therapeutics Oct 2010 - 114-23 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1521-0103

10.1124/jpet.110.168344 doi


Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Apoptosis Regulatory Proteins--antagonists & inhibitors
Arsenic Trioxide
Arsenicals--pharmacology
Blotting, Western
Cell Survival--drug effects
Curcumin--pharmacology
Electrophoretic Mobility Shift Assay
Flow Cytometry
Glutathione--metabolism
HL-60 Cells
Humans
Indazoles--pharmacology
Membrane Potentials--drug effects
Mitochondria--drug effects
Oxidants--pharmacology
Oxides--pharmacology
Protein Kinase Inhibitors--pharmacology
Protein Kinases--metabolism
Proto-Oncogene Proteins c-akt--biosynthesis
Reactive Oxygen Species--metabolism
U937 Cells