Dihydrotestosterone protects human vascular endothelial cells from H(2)O(2)-induced apoptosis through inhibition of caspase-3, caspase-9 and p38 MAPK.

Xu, Zhe-rong

Dihydrotestosterone protects human vascular endothelial cells from H(2)O(2)-induced apoptosis through inhibition of caspase-3, caspase-9 and p38 MAPK. [electronic resource] - European journal of pharmacology Sep 2010 - 254-9 p. digital

Publication Type: Journal Article

1879-0712

10.1016/j.ejphar.2010.06.039 doi


Androgens--pharmacology
Apoptosis--drug effects
Caspase 3--metabolism
Caspase 9--metabolism
Caspases--metabolism
Cell Line
Cell Survival--drug effects
Dihydrotestosterone--pharmacology
Down-Regulation--drug effects
Endothelium, Vascular--drug effects
Humans
Hydrogen Peroxide--toxicity
Mitochondria--drug effects
Osmolar Concentration
Oxidants--toxicity
Oxidative Stress--drug effects
Phosphorylation--drug effects
Plaque, Atherosclerotic--prevention & control
Protective Agents--pharmacology
p38 Mitogen-Activated Protein Kinases--metabolism