MGMT promoter hypermethylation is a frequent, early, and consistent event in astrocytoma progression, and not correlated with TP53 mutation.

Groenendijk, Floris H

MGMT promoter hypermethylation is a frequent, early, and consistent event in astrocytoma progression, and not correlated with TP53 mutation. [electronic resource] - Journal of neuro-oncology Feb 2011 - 405-17 p. digital

Publication Type: Journal Article

1573-7373

10.1007/s11060-010-0274-x doi


Adult
Astrocytoma--genetics
Brain Neoplasms--genetics
DNA Methylation
DNA Modification Methylases--genetics
DNA Repair Enzymes--genetics
Disease Progression
Female
Gene Expression Regulation, Neoplastic
Humans
Male
Middle Aged
Mutation--genetics
Prognosis
Promoter Regions, Genetic--genetics
Tumor Suppressor Protein p53--genetics
Tumor Suppressor Proteins--genetics