Efficient overcoming of drug resistance to anticancer nucleoside analogs by nanodelivery of active phosphorylated drugs.

Galmarini, Carlos M

Efficient overcoming of drug resistance to anticancer nucleoside analogs by nanodelivery of active phosphorylated drugs. [electronic resource] - International journal of pharmaceutics Aug 2010 - 281-9 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

1873-3476

10.1016/j.ijpharm.2010.05.028 doi


Animals
Antimetabolites, Antineoplastic--chemistry
Apoptosis--drug effects
Biological Transport
Cell Cycle--drug effects
Cell Line, Tumor
Cell Survival--drug effects
Chemistry, Pharmaceutical
Cytarabine--chemistry
Deoxycytidine--analogs & derivatives
Dose-Response Relationship, Drug
Drug Carriers
Drug Resistance
Drug Resistance, Neoplasm
Gels
Humans
Inhibitory Concentration 50
Mice
Mice, Inbred BALB C
Mice, Nude
Nanoparticles
Nanotechnology
Phosphorylation
Protein Tyrosine Phosphatase, Non-Receptor Type 22--metabolism
Technology, Pharmaceutical--methods
Time Factors
Tumor Burden--drug effects
Xenograft Model Antitumor Assays
Gemcitabine