ARQ 197, a novel and selective inhibitor of the human c-Met receptor tyrosine kinase with antitumor activity.
Munshi, Neru
ARQ 197, a novel and selective inhibitor of the human c-Met receptor tyrosine kinase with antitumor activity. [electronic resource] - Molecular cancer therapeutics Jun 2010 - 1544-53 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1538-8514
10.1158/1535-7163.MCT-09-1173 doi
Animals
Apoptosis--drug effects
Caspases--metabolism
Cell Line, Tumor
Cell Proliferation--drug effects
Humans
Immunosuppression Therapy
Mice
Mice, Nude
Neoplasms--enzymology
Phosphorylation--drug effects
Protein Kinase Inhibitors--chemistry
Proto-Oncogene Mas
Proto-Oncogene Proteins c-met--antagonists & inhibitors
Pyrroles--chemistry
Pyrrolidinones--chemistry
Quinolines--chemistry
Signal Transduction--drug effects
Xenograft Model Antitumor Assays
ARQ 197, a novel and selective inhibitor of the human c-Met receptor tyrosine kinase with antitumor activity. [electronic resource] - Molecular cancer therapeutics Jun 2010 - 1544-53 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1538-8514
10.1158/1535-7163.MCT-09-1173 doi
Animals
Apoptosis--drug effects
Caspases--metabolism
Cell Line, Tumor
Cell Proliferation--drug effects
Humans
Immunosuppression Therapy
Mice
Mice, Nude
Neoplasms--enzymology
Phosphorylation--drug effects
Protein Kinase Inhibitors--chemistry
Proto-Oncogene Mas
Proto-Oncogene Proteins c-met--antagonists & inhibitors
Pyrroles--chemistry
Pyrrolidinones--chemistry
Quinolines--chemistry
Signal Transduction--drug effects
Xenograft Model Antitumor Assays