Surfactant protein A2 mutations associated with pulmonary fibrosis lead to protein instability and endoplasmic reticulum stress.

Maitra, Meenakshi

Surfactant protein A2 mutations associated with pulmonary fibrosis lead to protein instability and endoplasmic reticulum stress. [electronic resource] - The Journal of biological chemistry Jul 2010 - 22103-13 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1083-351X

10.1074/jbc.M110.121467 doi


Amino Acid Substitution--drug effects
Animals
Biomarkers--metabolism
Bronchoalveolar Lavage Fluid--chemistry
Cell Extracts
Cell Line, Tumor
Detergents--pharmacology
Dogs
Endoplasmic Reticulum--drug effects
Female
Humans
Leupeptins--pharmacology
Male
Mutant Proteins--metabolism
Mutation--genetics
Pedigree
Protein Processing, Post-Translational--drug effects
Protein Stability--drug effects
Protein Structure, Quaternary
Pulmonary Alveoli--drug effects
Pulmonary Fibrosis--genetics
Pulmonary Surfactant-Associated Protein A--chemistry
Solubility--drug effects
Stress, Physiological--drug effects