Glucagon-like peptide 1 prevents reactive oxygen species-induced endothelial cell senescence through the activation of protein kinase A.

Oeseburg, Hisko

Glucagon-like peptide 1 prevents reactive oxygen species-induced endothelial cell senescence through the activation of protein kinase A. [electronic resource] - Arteriosclerosis, thrombosis, and vascular biology Jul 2010 - 1407-14 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1524-4636

10.1161/ATVBAHA.110.206425 doi


Adamantane--analogs & derivatives
Animals
Cells, Cultured
Cellular Senescence--drug effects
Cyclic AMP--metabolism
Cyclic AMP Response Element-Binding Protein--metabolism
Cyclic AMP-Dependent Protein Kinases--metabolism
DNA Damage
Diabetes Mellitus--drug therapy
Dipeptidyl-Peptidase IV Inhibitors--pharmacology
Disease Models, Animal
Dose-Response Relationship, Drug
Endothelial Cells--drug effects
Enzyme Activation
Exenatide
Glucagon-Like Peptide 1--metabolism
Glucagon-Like Peptide-1 Receptor
Heme Oxygenase-1--metabolism
Humans
Hydrogen Peroxide--pharmacology
Hypoglycemic Agents--pharmacology
Male
NAD(P)H Dehydrogenase (Quinone)--metabolism
Nitriles--pharmacology
Oxidants--pharmacology
Oxidative Stress--drug effects
Peptides--pharmacology
Phosphatidylinositol 3-Kinases--metabolism
Proto-Oncogene Proteins c-akt--metabolism
Pyrrolidines--pharmacology
Rats
Rats, Zucker
Reactive Oxygen Species--metabolism
Receptors, Glucagon--metabolism
Signal Transduction
Venoms--pharmacology
Vildagliptin