The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma.

Pechloff, Konstanze

The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma. [electronic resource] - The Journal of experimental medicine May 2010 - 1031-44 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1540-9538

10.1084/jem.20092042 doi


Animals
Antigens, CD--genetics
Antigens, Differentiation, T-Lymphocyte--genetics
Chromosomes, Human, Pair 5--genetics
Chromosomes, Human, Pair 9--genetics
Disease Models, Animal
Embryonic Stem Cells--physiology
Gene Expression Regulation, Neoplastic
Humans
Interleukin-2--genetics
Intracellular Signaling Peptides and Proteins--genetics
Lectins, C-Type--genetics
Lymphoma, T-Cell, Peripheral--genetics
Lymphoproliferative Disorders--genetics
Mice
Protein-Tyrosine Kinases--genetics
Receptors, Antigen, T-Cell--genetics
Recombinant Fusion Proteins--metabolism
Signal Transduction
Spleen--enzymology
Syk Kinase
Translocation, Genetic