Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism.

Xu, C-F

Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism. [electronic resource] - British journal of cancer Apr 2010 - 1371-7 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1532-1827

10.1038/sj.bjc.6605653 doi


Aged
Alanine Transaminase--metabolism
Antineoplastic Agents--adverse effects
Bilirubin--metabolism
Carcinoma, Renal Cell--drug therapy
Clinical Trials, Phase II as Topic
Clinical Trials, Phase III as Topic
Female
Genotype
Gilbert Disease--genetics
Glucuronosyltransferase--antagonists & inhibitors
Humans
Hyperbilirubinemia--chemically induced
Indazoles
Kidney Neoplasms--drug therapy
Liver--enzymology
Male
Middle Aged
Nephrectomy
Polymorphism, Genetic
Pyrimidines--adverse effects
Sulfonamides--adverse effects