Skp2 directs Myc-mediated suppression of p27Kip1 yet has modest effects on Myc-driven lymphomagenesis.

Old, Jennifer B

Skp2 directs Myc-mediated suppression of p27Kip1 yet has modest effects on Myc-driven lymphomagenesis. [electronic resource] - Molecular cancer research : MCR Mar 2010 - 353-62 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1557-3125

10.1158/1541-7786.MCR-09-0232 doi


Animals
CDC2-CDC28 Kinases
Carrier Proteins--genetics
Cell Proliferation
Cell Transformation, Neoplastic--genetics
Cells, Cultured
Cyclin-Dependent Kinase Inhibitor p27
Cyclin-Dependent Kinases--genetics
Gene Expression Regulation, Neoplastic--genetics
Humans
Intracellular Signaling Peptides and Proteins--genetics
Lymphoma, B-Cell--genetics
Mice
Mice, Inbred C57BL
Mice, Knockout
Proto-Oncogene Proteins c-myc--genetics
S-Phase Kinase-Associated Proteins--genetics
Tumor Cells, Cultured
Tumor Suppressor Proteins--genetics
Up-Regulation--physiology