Mice deficient in Mkp-1 develop more severe pulmonary hypertension and greater lung protein levels of arginase in response to chronic hypoxia.

Jin, Yi

Mice deficient in Mkp-1 develop more severe pulmonary hypertension and greater lung protein levels of arginase in response to chronic hypoxia. [electronic resource] - American journal of physiology. Heart and circulatory physiology May 2010 - H1518-28 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

1522-1539

10.1152/ajpheart.00813.2009 doi


Animals
Arginase--metabolism
Blotting, Western
Body Weight--physiology
Chronic Disease
Dual Specificity Phosphatase 1--genetics
Hypertension, Pulmonary--genetics
Hypoxia--genetics
Lung--metabolism
Mice
Mice, Inbred C57BL
Mice, Knockout
Myocardium--metabolism
Nitrates--metabolism
Nitric Oxide Synthase Type I--biosynthesis
Nitric Oxide Synthase Type II--biosynthesis
Nitric Oxide Synthase Type III--biosynthesis
Nitrites--metabolism
Proliferating Cell Nuclear Antigen--metabolism
Proteins--metabolism
Ventricular Function, Right--physiology
p38 Mitogen-Activated Protein Kinases--metabolism