Mechanistic characterization and molecular modeling of hepatitis B virus polymerase resistance to entecavir.

Walsh, Ann W

Mechanistic characterization and molecular modeling of hepatitis B virus polymerase resistance to entecavir. [electronic resource] - PloS one Feb 2010 - e9195 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1932-6203

10.1371/journal.pone.0009195 doi


Amino Acid Sequence
Amino Acid Substitution
Antiviral Agents--pharmacology
Binding Sites--genetics
Drug Resistance, Viral--genetics
Guanine--analogs & derivatives
Guanosine Triphosphate--chemistry
Hep G2 Cells
Hepatitis B virus--enzymology
Humans
Hydrogen Bonding
Kinetics
Lamivudine--pharmacology
Models, Molecular
Protein Binding
Protein Structure, Tertiary
RNA-Directed DNA Polymerase--chemistry
Substrate Specificity
Viral Proteins--chemistry
Virus Replication--drug effects