Homeostatic regulation of synaptic excitability: tonic GABA(A) receptor currents replace I(h) in cortical pyramidal neurons of HCN1 knock-out mice.

Chen, Xiangdong

Homeostatic regulation of synaptic excitability: tonic GABA(A) receptor currents replace I(h) in cortical pyramidal neurons of HCN1 knock-out mice. [electronic resource] - The Journal of neuroscience : the official journal of the Society for Neuroscience Feb 2010 - 2611-22 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1529-2401

10.1523/JNEUROSCI.3771-09.2010 doi


6-Cyano-7-nitroquinoxaline-2,3-dione--pharmacology
Animals
Anti-Anxiety Agents--pharmacology
Bicuculline--pharmacology
Cerebral Cortex--cytology
Cyclic Nucleotide-Gated Cation Channels--antagonists & inhibitors
Desoxycorticosterone--analogs & derivatives
Excitatory Amino Acid Antagonists--pharmacology
Excitatory Postsynaptic Potentials--drug effects
Female
GABA Agents--pharmacology
Homeostasis--genetics
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
Male
Membrane Potentials--drug effects
Mice
Mice, Inbred C57BL
Mice, Knockout
Models, Neurological
Patch-Clamp Techniques--methods
Potassium Channels--deficiency
Protein Subunits--genetics
Pyramidal Cells--physiology
Pyridazines--pharmacology
Pyrimidines--pharmacology
Receptors, GABA-A--physiology
Sodium Channel Blockers--pharmacology
Synapses--physiology
Tetrodotoxin--pharmacology
Up-Regulation--drug effects
Valine--analogs & derivatives