AC480, formerly BMS-599626, a pan Her inhibitor, enhances radiosensitivity and radioresponse of head and neck squamous cell carcinoma cells in vitro and in vivo.

Torres, Mylin A

AC480, formerly BMS-599626, a pan Her inhibitor, enhances radiosensitivity and radioresponse of head and neck squamous cell carcinoma cells in vitro and in vivo. [electronic resource] - Investigational new drugs Aug 2011 - 554-61 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1573-0646

10.1007/s10637-010-9389-3 doi


Animals
Apoptosis--drug effects
Blotting, Western
Carbamates--pharmacology
Carcinoma, Squamous Cell--drug therapy
Cell Count
Cell Cycle--drug effects
Cell Line, Tumor
Cell Proliferation--drug effects
ErbB Receptors--metabolism
Head and Neck Neoplasms--drug therapy
Histones--metabolism
Humans
Immunoprecipitation
Male
Mice
Mice, Nude
Radiation Tolerance--drug effects
Radiation, Ionizing
Receptor, ErbB-2--antagonists & inhibitors
Signal Transduction--drug effects
Triazines--pharmacology
Xenograft Model Antitumor Assays