Alkaline ceramidase 3 (ACER3) hydrolyzes unsaturated long-chain ceramides, and its down-regulation inhibits both cell proliferation and apoptosis.
Hu, Wei
Alkaline ceramidase 3 (ACER3) hydrolyzes unsaturated long-chain ceramides, and its down-regulation inhibits both cell proliferation and apoptosis. [electronic resource] - The Journal of biological chemistry Mar 2010 - 7964-76 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
1083-351X
10.1074/jbc.M109.063586 doi
Alkaline Ceramidase--genetics
Apoptosis--physiology
Carcinoma, Squamous Cell--pathology
Cell Division--physiology
Ceramidases--genetics
Ceramides--metabolism
Culture Media, Serum-Free--pharmacology
Cyclin-Dependent Kinase Inhibitor p21--metabolism
Down-Regulation--physiology
Endothelial Cells--cytology
Gene Expression Regulation, Enzymologic
HeLa Cells
Humans
Hydrolysis
Keratinocytes--cytology
Muscle, Smooth, Vascular--cytology
RNA, Messenger--metabolism
RNA, Small Interfering
Skin Neoplasms--pathology
Substrate Specificity
Umbilical Veins--cytology
Alkaline ceramidase 3 (ACER3) hydrolyzes unsaturated long-chain ceramides, and its down-regulation inhibits both cell proliferation and apoptosis. [electronic resource] - The Journal of biological chemistry Mar 2010 - 7964-76 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
1083-351X
10.1074/jbc.M109.063586 doi
Alkaline Ceramidase--genetics
Apoptosis--physiology
Carcinoma, Squamous Cell--pathology
Cell Division--physiology
Ceramidases--genetics
Ceramides--metabolism
Culture Media, Serum-Free--pharmacology
Cyclin-Dependent Kinase Inhibitor p21--metabolism
Down-Regulation--physiology
Endothelial Cells--cytology
Gene Expression Regulation, Enzymologic
HeLa Cells
Humans
Hydrolysis
Keratinocytes--cytology
Muscle, Smooth, Vascular--cytology
RNA, Messenger--metabolism
RNA, Small Interfering
Skin Neoplasms--pathology
Substrate Specificity
Umbilical Veins--cytology