Antifibrotic effect of Pirfenidone on orbital fibroblasts of patients with thyroid-associated ophthalmopathy by decreasing TIMP-1 and collagen levels.

Kim, Hyunmi

Antifibrotic effect of Pirfenidone on orbital fibroblasts of patients with thyroid-associated ophthalmopathy by decreasing TIMP-1 and collagen levels. [electronic resource] - Investigative ophthalmology & visual science Jun 2010 - 3061-6 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

1552-5783

10.1167/iovs.09-4257 doi


Adult
Aged
Anti-Inflammatory Agents, Non-Steroidal--pharmacology
Blotting, Western
Cell Culture Techniques
Cell Survival
Collagen--metabolism
Dexamethasone--pharmacology
Dose-Response Relationship, Drug
Enzyme-Linked Immunosorbent Assay
Female
Fibroblasts--drug effects
Graves Ophthalmopathy--metabolism
Humans
Hydroxyproline--metabolism
Intercellular Signaling Peptides and Proteins--pharmacology
Interleukin-1beta--pharmacology
Male
Middle Aged
Orbit--drug effects
Pyridones--pharmacology
Tissue Inhibitor of Metalloproteinase-1--metabolism
Tumor Necrosis Factor-alpha--antagonists & inhibitors
Young Adult