Corchorusin-D, a saikosaponin-like compound isolated from Corchorus acutangulus Lam., targets mitochondrial apoptotic pathways in leukemic cell lines (HL-60 and U937).

Mallick, Sumana

Corchorusin-D, a saikosaponin-like compound isolated from Corchorus acutangulus Lam., targets mitochondrial apoptotic pathways in leukemic cell lines (HL-60 and U937). [electronic resource] - Cancer chemotherapy and pharmacology Sep 2010 - 709-19 p. digital

Publication Type: Journal Article

1432-0843

10.1007/s00280-009-1214-3 doi


Antineoplastic Agents, Phytogenic--chemistry
Apoptosis--drug effects
Apoptosis Regulatory Proteins--genetics
Blotting, Western
Caspases--metabolism
Cell Nucleus--drug effects
Cell Proliferation--drug effects
Cell Survival--drug effects
Corchorus--chemistry
DNA Fragmentation--drug effects
Flow Cytometry
Glycosides--chemistry
HL-60 Cells
Humans
Leukemia--drug therapy
Membrane Potentials--drug effects
Methanol
Microscopy, Confocal
Mitochondria--drug effects
Mitochondrial Membranes--drug effects
Plant Extracts--pharmacology
Poly Adenosine Diphosphate Ribose--metabolism
Signal Transduction--drug effects
Triterpenes--chemistry
U937 Cells