Dexamethasone protects human fibroblasts from apoptosis via an S1P3-receptor subtype dependent activation of PKB/Akt and Bcl XL.

Nieuwenhuis, Barbara

Dexamethasone protects human fibroblasts from apoptosis via an S1P3-receptor subtype dependent activation of PKB/Akt and Bcl XL. [electronic resource] - Pharmacological research May 2010 - 449-59 p. digital

Publication Type: Journal Article

1096-1186

10.1016/j.phrs.2009.12.005 doi


Apoptosis--drug effects
Blotting, Western
Caspase 3--metabolism
Caspase 7--metabolism
Cells, Cultured
Dexamethasone--pharmacology
Fibroblasts--drug effects
Humans
Membrane Potentials--drug effects
Mitochondrial Membranes--drug effects
Oncogene Protein v-akt--metabolism
Phosphatidylinositol 3-Kinases--metabolism
Protective Agents
Proto-Oncogene Proteins c-akt--metabolism
RNA Interference
Receptors, Lysosphingolipid--metabolism
Reverse Transcriptase Polymerase Chain Reaction
Signal Transduction--drug effects
Tumor Necrosis Factor-alpha--metabolism
bcl-X Protein--metabolism