Posttranslational modification of ataxin-7 at lysine 257 prevents autophagy-mediated turnover of an N-terminal caspase-7 cleavage fragment.

Mookerjee, Shona

Posttranslational modification of ataxin-7 at lysine 257 prevents autophagy-mediated turnover of an N-terminal caspase-7 cleavage fragment. [electronic resource] - The Journal of neuroscience : the official journal of the Society for Neuroscience Dec 2009 - 15134-44 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

1529-2401

10.1523/JNEUROSCI.4720-09.2009 doi


Acetylation
Animals
Animals, Newborn
Ataxin-7
Autophagy--genetics
Caspase 7--genetics
Cells, Cultured
Cerebellum--cytology
Disease Models, Animal
Histone Deacetylases--genetics
Humans
Lysosomal-Associated Membrane Protein 2--metabolism
Mice
Mice, Transgenic
Mucoproteins--genetics
Nerve Tissue Proteins--genetics
Neurons--physiology
Peptides--genetics
Prions--genetics
Protein Processing, Post-Translational--genetics
Protein Subunits--genetics
RNA Interference--physiology
Spinocerebellar Ataxias--genetics
Transfection--methods