Cadmium-induced DNA damage triggers G(2)/M arrest via chk1/2 and cdc2 in p53-deficient kidney proximal tubule cells.

Bork, Ulrich

Cadmium-induced DNA damage triggers G(2)/M arrest via chk1/2 and cdc2 in p53-deficient kidney proximal tubule cells. [electronic resource] - American journal of physiology. Renal physiology Feb 2010 - F255-65 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1522-1466

10.1152/ajprenal.00273.2009 doi


Animals
Ataxia Telangiectasia Mutated Proteins
Cadmium--pharmacology
Cell Cycle--drug effects
Cell Cycle Proteins--metabolism
Cell Death
Cell Division--drug effects
Cells, Cultured
Checkpoint Kinase 1
Checkpoint Kinase 2
Cyclin B--metabolism
DNA Damage
DNA-Binding Proteins--metabolism
G2 Phase--drug effects
Kidney Tubules, Proximal--cytology
Phosphorylation--drug effects
Protein Kinase Inhibitors--pharmacology
Protein Kinases--drug effects
Protein Serine-Threonine Kinases--antagonists & inhibitors
Rats
Reactive Oxygen Species--metabolism
Signal Transduction
Staurosporine--analogs & derivatives
Tumor Suppressor Protein p53--deficiency
Tumor Suppressor Proteins--metabolism