Induction of p53 renders ATM-deficient mice refractory to hepatocarcinogenesis.

Teoh, Narci

Induction of p53 renders ATM-deficient mice refractory to hepatocarcinogenesis. [electronic resource] - Gastroenterology Mar 2010 - 1155-65.e1-2 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1528-0012

10.1053/j.gastro.2009.11.008 doi


Animals
Apoptosis
Ataxia Telangiectasia Mutated Proteins
Carcinoma, Hepatocellular--chemically induced
Caspase 3--metabolism
Cell Cycle
Cell Cycle Proteins--genetics
Cell Transformation, Neoplastic--chemically induced
Cellular Senescence
Checkpoint Kinase 1
Chromosome Aberrations
Cyclin-Dependent Kinase Inhibitor p16--metabolism
DNA-Binding Proteins--deficiency
Diethylnitrosamine
Disease Models, Animal
Gene Expression Regulation, Neoplastic
Heterozygote
Karyotyping
Liver Neoplasms--chemically induced
Male
Mice
Mice, Knockout
Protein Kinases--metabolism
Protein Serine-Threonine Kinases--deficiency
Signal Transduction
Telomerase--metabolism
Time Factors
Tumor Suppressor Protein p53--genetics
Tumor Suppressor Proteins--deficiency
Up-Regulation