Zoledronic acid delays wound healing of the tooth extraction socket, inhibits oral epithelial cell migration, and promotes proliferation and adhesion to hydroxyapatite of oral bacteria, without causing osteonecrosis of the jaw, in mice.

Kobayashi, Yasuyoshi

Zoledronic acid delays wound healing of the tooth extraction socket, inhibits oral epithelial cell migration, and promotes proliferation and adhesion to hydroxyapatite of oral bacteria, without causing osteonecrosis of the jaw, in mice. [electronic resource] - Journal of bone and mineral metabolism Mar 2010 - 165-75 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

1435-5604

10.1007/s00774-009-0128-9 doi


Animals
Bacterial Adhesion--drug effects
Bacterial Physiological Phenomena--drug effects
Bone Density Conservation Agents--administration & dosage
Cell Movement--drug effects
Cell Proliferation--drug effects
Cells, Cultured
Dental Plaque--microbiology
Diphosphonates--administration & dosage
Dose-Response Relationship, Drug
Female
Humans
Imidazoles--administration & dosage
Jaw Diseases--physiopathology
Male
Mice
Mice, Inbred Strains
Mouth Mucosa--drug effects
Neovascularization, Physiologic--drug effects
Osteogenesis--drug effects
Osteonecrosis--physiopathology
Streptococcus mutans--drug effects
Tooth Extraction
Tooth Socket--pathology
Wound Healing--drug effects
Zoledronic Acid