A feedback loop involving the Phd3 prolyl hydroxylase tunes the mammalian hypoxic response in vivo.

Minamishima, Yoji Andrew

A feedback loop involving the Phd3 prolyl hydroxylase tunes the mammalian hypoxic response in vivo. [electronic resource] - Molecular and cellular biology Nov 2009 - 5729-41 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1098-5549

10.1128/MCB.00331-09 doi


Animals
Cardiomegaly--complications
Cardiomyopathies--complications
Cell Hypoxia
Enzyme Activation
Feedback, Physiological
Heart Function Tests
Hypoxia-Inducible Factor 1, alpha Subunit--metabolism
Hypoxia-Inducible Factor-Proline Dioxygenases
Kidney--enzymology
Liver--enzymology
Mammals--metabolism
Mice
Mitochondria--enzymology
Myocardium--enzymology
Polycythemia--complications
Procollagen-Proline Dioxygenase--deficiency
Survival Analysis
Von Hippel-Lindau Tumor Suppressor Protein--metabolism