C-5 Substituted heteroaryl 3-pyridinecarbonitriles as PKCtheta inhibitors: Part I.

Subrath, Joan

C-5 Substituted heteroaryl 3-pyridinecarbonitriles as PKCtheta inhibitors: Part I. [electronic resource] - Bioorganic & medicinal chemistry letters Sep 2009 - 5423-5 p. digital

Publication Type: Journal Article

1464-3405

10.1016/j.bmcl.2009.07.109 doi


Animals
Inhibitory Concentration 50
Isoenzymes--antagonists & inhibitors
Mice
Mice, Knockout
Nitriles--chemistry
Protein Kinase C--antagonists & inhibitors
Protein Kinase C-theta
Protein Kinase Inhibitors--chemistry
Pyridines--chemistry
Structure-Activity Relationship
T-Lymphocytes--drug effects