Mouse specific lung tumors from CYP2F2-mediated cytotoxic metabolism: an endpoint/toxic response where data from multiple chemicals converge to support a mode of action.
Cruzan, George
Mouse specific lung tumors from CYP2F2-mediated cytotoxic metabolism: an endpoint/toxic response where data from multiple chemicals converge to support a mode of action. [electronic resource] - Regulatory toxicology and pharmacology : RTP Nov 2009 - 205-18 p. digital
Publication Type: Journal Article; Review
1096-0295
10.1016/j.yrtph.2009.07.002 doi
Adenocarcinoma--chemically induced
Adenoma--chemically induced
Animals
Bronchioles--drug effects
Carcinogens--chemistry
Cell Proliferation--drug effects
Coumarins--chemistry
Cytochrome P-450 Enzyme Inhibitors
Cytochrome P-450 Enzyme System--metabolism
Disease Models, Animal
Endpoint Determination
Enzyme Inhibitors--pharmacology
Epithelial Cells--drug effects
Humans
Inhalation Exposure
Isoenzymes
Lung Neoplasms--chemically induced
Mice
Mice, Knockout
Mutagenicity Tests
Naphthalenes--chemistry
Rats
Structure-Activity Relationship
Styrene--chemistry
Mouse specific lung tumors from CYP2F2-mediated cytotoxic metabolism: an endpoint/toxic response where data from multiple chemicals converge to support a mode of action. [electronic resource] - Regulatory toxicology and pharmacology : RTP Nov 2009 - 205-18 p. digital
Publication Type: Journal Article; Review
1096-0295
10.1016/j.yrtph.2009.07.002 doi
Adenocarcinoma--chemically induced
Adenoma--chemically induced
Animals
Bronchioles--drug effects
Carcinogens--chemistry
Cell Proliferation--drug effects
Coumarins--chemistry
Cytochrome P-450 Enzyme Inhibitors
Cytochrome P-450 Enzyme System--metabolism
Disease Models, Animal
Endpoint Determination
Enzyme Inhibitors--pharmacology
Epithelial Cells--drug effects
Humans
Inhalation Exposure
Isoenzymes
Lung Neoplasms--chemically induced
Mice
Mice, Knockout
Mutagenicity Tests
Naphthalenes--chemistry
Rats
Structure-Activity Relationship
Styrene--chemistry