Small intestinal efflux mediated by MRP2 and BCRP shifts sulfasalazine intestinal permeability from high to low, enabling its colonic targeting.

Dahan, Arik

Small intestinal efflux mediated by MRP2 and BCRP shifts sulfasalazine intestinal permeability from high to low, enabling its colonic targeting. [electronic resource] - American journal of physiology. Gastrointestinal and liver physiology Aug 2009 - G371-7 p. digital

Publication Type: Journal Article

1522-1547

10.1152/ajpgi.00102.2009 doi


2-Pyridinylmethylsulfinylbenzimidazoles--pharmacology
ATP Binding Cassette Transporter, Subfamily B, Member 1--metabolism
ATP Binding Cassette Transporter, Subfamily G, Member 2
ATP-Binding Cassette Transporters--antagonists & inhibitors
Administration, Oral
Animals
Biological Transport
Caco-2 Cells
Colon--drug effects
Dose-Response Relationship, Drug
Drug Delivery Systems
Humans
Indoles--pharmacology
Indomethacin--pharmacology
Intestinal Absorption
Intestine, Small--drug effects
Kinetics
Male
Multidrug Resistance-Associated Protein 2
Multidrug Resistance-Associated Proteins--antagonists & inhibitors
Neoplasm Proteins--antagonists & inhibitors
Pantoprazole
Perfusion
Permeability
Propionates--pharmacology
Quinolines--pharmacology
Rats
Rats, Wistar
Sulfasalazine--administration & dosage