Impairment of APE1 function enhances cellular sensitivity to clinically relevant alkylators and antimetabolites.

McNeill, Daniel R

Impairment of APE1 function enhances cellular sensitivity to clinically relevant alkylators and antimetabolites. [electronic resource] - Molecular cancer research : MCR Jun 2009 - 897-906 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural

1557-3125

10.1158/1541-7786.MCR-08-0519 doi


Animals
Antimetabolites, Antineoplastic--pharmacology
Antineoplastic Agents, Alkylating--pharmacology
Apoptosis--drug effects
CHO Cells
Cell Cycle--drug effects
Cell Survival--drug effects
Cricetinae
Cricetulus
DNA Repair
DNA-(Apurinic or Apyrimidinic Site) Lyase--biosynthesis
Fluorouracil--pharmacology
G1 Phase--drug effects
Humans
Mutation
Neoplasms--drug therapy