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PPARgamma and RXRgamma ligands act synergistically as potent antineoplastic agents in vitro and in vivo glioma models.

Papi, Alessio

PPARgamma and RXRgamma ligands act synergistically as potent antineoplastic agents in vitro and in vivo glioma models. [electronic resource] - Journal of neurochemistry Jun 2009 - 1779-90 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

ISSN: 1471-4159

Standard No.: 10.1111/j.1471-4159.2009.06111.x doi

Subjects--Topical Terms:
Analysis of Variance
Animals
Annexin A5--metabolism
Antineoplastic Agents--therapeutic use
Brain Neoplasms--drug therapy
Bromodeoxyuridine--metabolism
Caspase 3--metabolism
Cell Line, Tumor
Cell Proliferation
Cytochromes c--metabolism
Disease Models, Animal
Dose-Response Relationship, Drug
Drug Synergism
Gene Expression Regulation, Neoplastic--drug effects
Glioma--drug therapy
Humans
Ligands
Matrix Metalloproteinases--metabolism
Mice
Mice, Inbred C57BL
Neoplasm Invasiveness--physiopathology
PPAR gamma--metabolism
Pioglitazone
Proto-Oncogene Proteins c-bcl-2--metabolism
Rats
Retinoid X Receptor gamma--metabolism
Tetrazolium Salts
Thiazoles
Thiazolidinediones--therapeutic use
Transfection--methods
Tretinoin--analogs & derivatives
Tumor Stem Cell Assay--methods
bcl-2-Associated X Protein--metabolism