The selective 5-hydroxytryptamine 1A antagonist, AZD7371 [3(R)-(N,N-dicyclobutylamino)-8-fluoro-3,4-dihydro-2H-1-benzopyran-5-carboxamide (R,R)-tartrate monohydrate] (robalzotan tartrate monohydrate), inhibits visceral pain-related visceromotor, but not autonomic cardiovascular, responses to colorectal distension in rats.

Lindström, E

The selective 5-hydroxytryptamine 1A antagonist, AZD7371 [3(R)-(N,N-dicyclobutylamino)-8-fluoro-3,4-dihydro-2H-1-benzopyran-5-carboxamide (R,R)-tartrate monohydrate] (robalzotan tartrate monohydrate), inhibits visceral pain-related visceromotor, but not autonomic cardiovascular, responses to colorectal distension in rats. [electronic resource] - The Journal of pharmacology and experimental therapeutics Jun 2009 - 1048-55 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1521-0103

10.1124/jpet.109.152330 doi


Abdominal Muscles--drug effects
Abdominal Pain--drug therapy
Animals
Benzopyrans--administration & dosage
Blood Pressure--drug effects
Cardiovascular Physiological Phenomena--drug effects
Colonic Diseases--complications
Dilatation, Pathologic--complications
Disease Models, Animal
Dose-Response Relationship, Drug
Female
Heart Rate--drug effects
Piperazines--pharmacology
Pyridines--pharmacology
Rats
Rats, Sprague-Dawley
Serotonin 5-HT1 Receptor Antagonists
Serotonin Antagonists--administration & dosage
Urination--drug effects