An orally bioavailable synthetic analog of an active dehydroepiandrosterone metabolite reduces established disease in rodent models of rheumatoid arthritis.

Offner, Halina

An orally bioavailable synthetic analog of an active dehydroepiandrosterone metabolite reduces established disease in rodent models of rheumatoid arthritis. [electronic resource] - The Journal of pharmacology and experimental therapeutics Jun 2009 - 1100-9 p. digital

Publication Type: Journal Article

1521-0103

10.1124/jpet.108.145086 doi


Animals
Anti-Inflammatory Agents--administration & dosage
Antibodies--immunology
Antibody Formation--drug effects
Arthritis, Rheumatoid--chemically induced
Collagen--immunology
Cytokines--genetics
Dehydroepiandrosterone--administration & dosage
Disease Models, Animal
Gene Expression--drug effects
Hypersensitivity, Delayed--immunology
Immune System--drug effects
Interleukin-6--genetics
Joints--drug effects
Lipopolysaccharides--pharmacology
Lymph Nodes--drug effects
Male
Matrix Metalloproteinase 3--genetics
Mice
Mice, Inbred DBA
Mice, Inbred ICR
NF-kappa B--metabolism
Spleen--drug effects