The ataxia3 mutation in the N-terminal cytoplasmic domain of sodium channel Na(v)1.6 disrupts intracellular trafficking.

Sharkey, Lisa M

The ataxia3 mutation in the N-terminal cytoplasmic domain of sodium channel Na(v)1.6 disrupts intracellular trafficking. [electronic resource] - The Journal of neuroscience : the official journal of the Society for Neuroscience Mar 2009 - 2733-41 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

1529-2401

10.1523/JNEUROSCI.6026-08.2009 doi


Animals
Blotting, Western
Cell Line
Chromosome Mapping
Cytoplasm--metabolism
DNA, Complementary--biosynthesis
Data Interpretation, Statistical
Electrophysiology
Ethylnitrosourea
Immunohistochemistry
Machado-Joseph Disease--genetics
Mice
Mice, Inbred C57BL
Mutagens
Mutation--genetics
Mutation, Missense--genetics
NAV1.6 Voltage-Gated Sodium Channel
Nerve Tissue Proteins--genetics
Patch-Clamp Techniques
Sciatic Nerve--pathology
Sodium Channels--genetics
Subcellular Fractions--metabolism
Transfection