Synergistic activation of glucose-6-phosphate dehydrogenase and NAD(P)H oxidase by Src kinase elevates superoxide in type 2 diabetic, Zucker fa/fa, rat liver.

Gupte, Rakhee S

Synergistic activation of glucose-6-phosphate dehydrogenase and NAD(P)H oxidase by Src kinase elevates superoxide in type 2 diabetic, Zucker fa/fa, rat liver. [electronic resource] - Free radical biology & medicine Aug 2009 - 219-28 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1873-4596

10.1016/j.freeradbiomed.2009.01.028 doi


6-Aminonicotinamide--pharmacology
Animals
Cell Extracts
Cells, Cultured
Dehydroepiandrosterone--pharmacology
Diabetes Mellitus, Type 2--enzymology
Enzyme Inhibitors--pharmacology
Gene Expression Regulation, Enzymologic--drug effects
Gluconates--pharmacology
Glucosephosphate Dehydrogenase--genetics
Glycoproteins--pharmacology
Liver--drug effects
Male
NADPH Oxidases--genetics
Obesity
Pentose Phosphate Pathway--drug effects
Perfusion
Phosphatidylinositol 3-Kinases--metabolism
Rats
Rats, Zucker
Signal Transduction
Superoxides--metabolism
Up-Regulation--drug effects
src-Family Kinases--metabolism