Ggamma1, a downstream target for the hmgcr-isoprenoid biosynthetic pathway, is required for releasing the Hedgehog ligand and directing germ cell migration.

Deshpande, Girish

Ggamma1, a downstream target for the hmgcr-isoprenoid biosynthetic pathway, is required for releasing the Hedgehog ligand and directing germ cell migration. [electronic resource] - PLoS genetics Jan 2009 - e1000333 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

1553-7404

10.1371/journal.pgen.1000333 doi


Animals
Animals, Genetically Modified
Cell Movement
Dimethylallyltranstransferase--genetics
Drosophila--cytology
Drosophila Proteins--genetics
Farnesyltranstransferase--genetics
Female
GTP-Binding Protein gamma Subunits--genetics
Germ Cells--physiology
Hedgehog Proteins--genetics
Hydroxymethylglutaryl CoA Reductases--genetics
Male
Metabolic Networks and Pathways--genetics
Mevalonic Acid--metabolism
Mutation
Protein Processing, Post-Translational--genetics
Receptors, G-Protein-Coupled--genetics
Smoothened Receptor
Terpenes--metabolism
Wings, Animal--anatomy & histology