Isoxazolo[3,4-b]quinoline-3,4(1H,9H)-diones as unique, potent and selective inhibitors for Pim-1 and Pim-2 kinases: chemistry, biological activities, and molecular modeling.

Tong, Yunsong

Isoxazolo[3,4-b]quinoline-3,4(1H,9H)-diones as unique, potent and selective inhibitors for Pim-1 and Pim-2 kinases: chemistry, biological activities, and molecular modeling. [electronic resource] - Bioorganic & medicinal chemistry letters Oct 2008 - 5206-8 p. digital

Publication Type: Journal Article

1464-3405

10.1016/j.bmcl.2008.08.079 doi


Combinatorial Chemistry Techniques
Crystallography, X-Ray
Humans
Isoxazoles--chemical synthesis
Models, Molecular
Molecular Conformation
Molecular Structure
Protein Serine-Threonine Kinases--antagonists & inhibitors
Proto-Oncogene Proteins--antagonists & inhibitors
Proto-Oncogene Proteins c-pim-1--antagonists & inhibitors
Quinolines--chemical synthesis
Structure-Activity Relationship