Detection of human survival motor neuron (SMN) protein in mice containing the SMN2 transgene: applicability to preclinical therapy development for spinal muscular atrophy.
Mattis, Virginia B
Detection of human survival motor neuron (SMN) protein in mice containing the SMN2 transgene: applicability to preclinical therapy development for spinal muscular atrophy. [electronic resource] - Journal of neuroscience methods Oct 2008 - 36-43 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
0165-0270
10.1016/j.jneumeth.2008.07.024 doi
Alternative Splicing--genetics
Amino Acid Sequence
Animals
Antibodies, Monoclonal--metabolism
Cells, Cultured
Disease Models, Animal
Enzyme Inhibitors
Epitope Mapping--methods
Fibroblasts--drug effects
Gene Expression Regulation--drug effects
Humans
Hydroxyurea--therapeutic use
Indoles
Mice
Mice, Transgenic--metabolism
Muscular Atrophy, Spinal--drug therapy
SMN Complex Proteins--genetics
Spinal Cord--drug effects
Survival of Motor Neuron 2 Protein
Valproic Acid--therapeutic use
Detection of human survival motor neuron (SMN) protein in mice containing the SMN2 transgene: applicability to preclinical therapy development for spinal muscular atrophy. [electronic resource] - Journal of neuroscience methods Oct 2008 - 36-43 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
0165-0270
10.1016/j.jneumeth.2008.07.024 doi
Alternative Splicing--genetics
Amino Acid Sequence
Animals
Antibodies, Monoclonal--metabolism
Cells, Cultured
Disease Models, Animal
Enzyme Inhibitors
Epitope Mapping--methods
Fibroblasts--drug effects
Gene Expression Regulation--drug effects
Humans
Hydroxyurea--therapeutic use
Indoles
Mice
Mice, Transgenic--metabolism
Muscular Atrophy, Spinal--drug therapy
SMN Complex Proteins--genetics
Spinal Cord--drug effects
Survival of Motor Neuron 2 Protein
Valproic Acid--therapeutic use