A RAG1 mutation found in Omenn syndrome causes coding flank hypersensitivity: a novel mechanism for antigen receptor repertoire restriction.

Wong, Serre-Yu

A RAG1 mutation found in Omenn syndrome causes coding flank hypersensitivity: a novel mechanism for antigen receptor repertoire restriction. [electronic resource] - Journal of immunology (Baltimore, Md. : 1950) Sep 2008 - 4124-30 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1550-6606

10.4049/jimmunol.181.6.4124 doi


Amino Acid Motifs--genetics
Amino Acid Substitution--genetics
Animals
Arginine--genetics
CHO Cells
Catalytic Domain--genetics
Cricetinae
Cricetulus
Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
Genes, T-Cell Receptor beta--genetics
Glutamine--genetics
Homeodomain Proteins--genetics
Humans
Mice
Mutagenesis, Site-Directed
Severe Combined Immunodeficiency--enzymology
VDJ Recombinases--genetics