Aberrant Rheb-mediated mTORC1 activation and Pten haploinsufficiency are cooperative oncogenic events.
Nardella, Caterina
Aberrant Rheb-mediated mTORC1 activation and Pten haploinsufficiency are cooperative oncogenic events. [electronic resource] - Genes & development Aug 2008 - 2172-7 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
0890-9369
10.1101/gad.1699608 doi
Animals
Blotting, Western
Cell Line, Tumor
Cell Transformation, Neoplastic--pathology
Chromosome Aberrations
Humans
Male
Mechanistic Target of Rapamycin Complex 1
Mice
Mice, Transgenic
Monomeric GTP-Binding Proteins--physiology
Multiprotein Complexes
Neuropeptides--physiology
PTEN Phosphohydrolase--physiology
Prostatic Intraepithelial Neoplasia--etiology
Prostatic Neoplasms--etiology
Proteins
Proto-Oncogene Mas
RNA, Messenger--genetics
Ras Homolog Enriched in Brain Protein
Reverse Transcriptase Polymerase Chain Reaction
Signal Transduction
TOR Serine-Threonine Kinases
Transcription Factors--physiology
Aberrant Rheb-mediated mTORC1 activation and Pten haploinsufficiency are cooperative oncogenic events. [electronic resource] - Genes & development Aug 2008 - 2172-7 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
0890-9369
10.1101/gad.1699608 doi
Animals
Blotting, Western
Cell Line, Tumor
Cell Transformation, Neoplastic--pathology
Chromosome Aberrations
Humans
Male
Mechanistic Target of Rapamycin Complex 1
Mice
Mice, Transgenic
Monomeric GTP-Binding Proteins--physiology
Multiprotein Complexes
Neuropeptides--physiology
PTEN Phosphohydrolase--physiology
Prostatic Intraepithelial Neoplasia--etiology
Prostatic Neoplasms--etiology
Proteins
Proto-Oncogene Mas
RNA, Messenger--genetics
Ras Homolog Enriched in Brain Protein
Reverse Transcriptase Polymerase Chain Reaction
Signal Transduction
TOR Serine-Threonine Kinases
Transcription Factors--physiology