A strategy for systemic delivery of the oncolytic herpes virus HSV1716: redirected tropism by antibody-binding sites incorporated on the virion surface as a glycoprotein D fusion protein.

Conner, J

A strategy for systemic delivery of the oncolytic herpes virus HSV1716: redirected tropism by antibody-binding sites incorporated on the virion surface as a glycoprotein D fusion protein. [electronic resource] - Gene therapy Dec 2008 - 1579-92 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1476-5462

10.1038/gt.2008.121 doi


ADP-ribosyl Cyclase 1--immunology
Animals
Binding Sites, Antibody--genetics
CD55 Antigens--immunology
CHO Cells
Cricetinae
Cricetulus
ErbB Receptors--immunology
Fluorescent Antibody Technique
Genetic Therapy--methods
Glycoproteins--genetics
Humans
Immunoglobulin Variable Region--genetics
Injections, Intraperitoneal
Mice
Mice, Nude
Microscopy, Fluorescence
Neoplasms--immunology
Oncolytic Virotherapy--methods
Oncolytic Viruses--genetics
Recombinant Fusion Proteins--administration & dosage
Simplexvirus--genetics