An automated, high-throughput, 384 well Cytochrome P450 cocktail IC50 assay using a rapid resolution LC-MS/MS end-point.

Youdim, Kuresh A

An automated, high-throughput, 384 well Cytochrome P450 cocktail IC50 assay using a rapid resolution LC-MS/MS end-point. [electronic resource] - Journal of pharmaceutical and biomedical analysis Sep 2008 - 92-9 p. digital

Publication Type: Journal Article

0731-7085

10.1016/j.jpba.2008.05.011 doi


Aryl Hydrocarbon Hydroxylases--analysis
Biological Assay
Chromatography, Liquid--methods
Cytochrome P-450 CYP1A2--analysis
Cytochrome P-450 CYP2B6
Cytochrome P-450 CYP2C19
Cytochrome P-450 CYP2C9
Cytochrome P-450 CYP2D6--analysis
Cytochrome P-450 CYP3A--analysis
Cytochrome P-450 Enzyme System--analysis
Dextromethorphan--metabolism
Diclofenac--metabolism
Drug Interactions
Humans
Hydrogen-Ion Concentration
Inhibitory Concentration 50
Kinetics
Microsomes, Liver--chemistry
Midazolam--metabolism
Miniaturization
Oxidoreductases, N-Demethylating--metabolism
Reference Standards
Reproducibility of Results
Sensitivity and Specificity
Substrate Specificity--drug effects
Tacrine--metabolism
Tandem Mass Spectrometry--methods
Time Factors