To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions.

Dewson, Grant

To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions. [electronic resource] - Molecular cell May 2008 - 369-80 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1097-4164

10.1016/j.molcel.2008.04.005 doi


Amino Acid Sequence
Animals
Apoptosis--physiology
Apoptosis Regulatory Proteins--genetics
BH3 Interacting Domain Death Agonist Protein--genetics
Bcl-2-Like Protein 11
Cells, Cultured
Dimerization
Disulfides--chemistry
Fibroblasts--cytology
Humans
Membrane Proteins--genetics
Mice
Mice, Knockout
Models, Molecular
Molecular Sequence Data
Mutation
Protein Conformation
Proto-Oncogene Proteins--genetics
Signal Transduction--physiology
bcl-2 Homologous Antagonist-Killer Protein--chemistry
bcl-2-Associated X Protein--genetics