Multiple molecular pathways are involved in the neuroprotection of GDNF against proteasome inhibitor induced dopamine neuron degeneration in vivo.
Du, Yunlan
Multiple molecular pathways are involved in the neuroprotection of GDNF against proteasome inhibitor induced dopamine neuron degeneration in vivo. [electronic resource] - Experimental biology and medicine (Maywood, N.J.) Jul 2008 - 881-90 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1535-3702
10.3181/0712-RM-329 doi
Acetylcysteine--adverse effects
Animals
Cysteine Proteinase Inhibitors--adverse effects
Disease Models, Animal
Dopamine--metabolism
Glial Cell Line-Derived Neurotrophic Factor--therapeutic use
JNK Mitogen-Activated Protein Kinases--metabolism
Male
Mice
Mice, Inbred C57BL
Mitogen-Activated Protein Kinase Kinases--metabolism
Nerve Degeneration--metabolism
Parkinson Disease--etiology
Phosphatidylinositol 3-Kinases--metabolism
Proteasome Inhibitors
Proto-Oncogene Proteins c-akt--metabolism
Random Allocation
Signal Transduction--drug effects
Substantia Nigra--drug effects
p38 Mitogen-Activated Protein Kinases--metabolism
Multiple molecular pathways are involved in the neuroprotection of GDNF against proteasome inhibitor induced dopamine neuron degeneration in vivo. [electronic resource] - Experimental biology and medicine (Maywood, N.J.) Jul 2008 - 881-90 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1535-3702
10.3181/0712-RM-329 doi
Acetylcysteine--adverse effects
Animals
Cysteine Proteinase Inhibitors--adverse effects
Disease Models, Animal
Dopamine--metabolism
Glial Cell Line-Derived Neurotrophic Factor--therapeutic use
JNK Mitogen-Activated Protein Kinases--metabolism
Male
Mice
Mice, Inbred C57BL
Mitogen-Activated Protein Kinase Kinases--metabolism
Nerve Degeneration--metabolism
Parkinson Disease--etiology
Phosphatidylinositol 3-Kinases--metabolism
Proteasome Inhibitors
Proto-Oncogene Proteins c-akt--metabolism
Random Allocation
Signal Transduction--drug effects
Substantia Nigra--drug effects
p38 Mitogen-Activated Protein Kinases--metabolism