The stepwise specification of embryonic stem cells to hematopoietic fate is driven by sequential exposure to Bmp4, activin A, bFGF and VEGF.

Pearson, Stella

The stepwise specification of embryonic stem cells to hematopoietic fate is driven by sequential exposure to Bmp4, activin A, bFGF and VEGF. [electronic resource] - Development (Cambridge, England) Apr 2008 - 1525-35 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0950-1991

10.1242/dev.011767 doi


Activins--pharmacology
Adaptor Proteins, Signal Transducing
Animals
Basic Helix-Loop-Helix Transcription Factors--genetics
Bone Morphogenetic Protein 4
Bone Morphogenetic Proteins--pharmacology
Cell Differentiation--drug effects
Cells, Cultured
Core Binding Factor Alpha 2 Subunit--genetics
Culture Media, Serum-Free
DNA-Binding Proteins--genetics
Embryonic Stem Cells--cytology
Fibroblast Growth Factor 2--pharmacology
Gene Expression Regulation, Developmental--drug effects
Hematopoiesis--drug effects
Hematopoietic Stem Cells--cytology
Homeodomain Proteins--genetics
LIM Domain Proteins
Metalloproteins--genetics
Mice
Proto-Oncogene Protein c-fli-1--genetics
Proto-Oncogene Proteins--genetics
Recombinant Proteins--pharmacology
T-Cell Acute Lymphocytic Leukemia Protein 1
Transcription Factors--genetics
Vascular Endothelial Growth Factor A--pharmacology