Dimemorfan protects rats against ischemic stroke through activation of sigma-1 receptor-mediated mechanisms by decreasing glutamate accumulation.

Shen, Yuh-Chiang

Dimemorfan protects rats against ischemic stroke through activation of sigma-1 receptor-mediated mechanisms by decreasing glutamate accumulation. [electronic resource] - Journal of neurochemistry Jan 2008 - 558-72 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1471-4159

10.1111/j.1471-4159.2007.05058.x doi


Analysis of Variance
Animals
Brain Infarction--etiology
Brain Ischemia--drug therapy
Chemokine CCL2--metabolism
Disease Models, Animal
Dose-Response Relationship, Drug
Gene Expression Regulation--drug effects
Glutamic Acid--metabolism
Lipid Peroxidation--drug effects
Male
Morphinans--therapeutic use
Morpholines--pharmacology
Nitric Oxide Synthase--metabolism
Peroxidase--metabolism
Protein Serine-Threonine Kinases--metabolism
Rats
Rats, Long-Evans
Receptors, sigma--agonists
Reperfusion Injury--prevention & control
STAT1 Transcription Factor--metabolism
Signal Transduction--drug effects
Sigma-1 Receptor
NF-kappaB-Inducing Kinase