Intrathecal delivery of hepatocyte growth factor from amyotrophic lateral sclerosis onset suppresses disease progression in rat amyotrophic lateral sclerosis model.

Ishigaki, Aya

Intrathecal delivery of hepatocyte growth factor from amyotrophic lateral sclerosis onset suppresses disease progression in rat amyotrophic lateral sclerosis model. [electronic resource] - Journal of neuropathology and experimental neurology Nov 2007 - 1037-44 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0022-3069

10.1097/nen.0b013e318159886b doi


Amyotrophic Lateral Sclerosis--drug therapy
Animals
Animals, Genetically Modified
Blotting, Western
Caspases--drug effects
Disease Models, Animal
Disease Progression
Enzyme-Linked Immunosorbent Assay
Excitatory Amino Acid Transporter 2--drug effects
Hepatocyte Growth Factor--administration & dosage
Humans
Immunohistochemistry
Infusion Pumps, Implantable
Injections, Spinal
Motor Neurons--drug effects
Nerve Degeneration--drug therapy
Proto-Oncogene Proteins c-met--metabolism
RNA, Messenger--analysis
Rats
Reverse Transcriptase Polymerase Chain Reaction
Spinal Cord--drug effects
X-Linked Inhibitor of Apoptosis Protein--drug effects