Macrocyclic ureas as potent and selective Chk1 inhibitors: an improved synthesis, kinome profiling, structure-activity relationships, and preliminary pharmacokinetics.
Tao, Zhi-Fu
Macrocyclic ureas as potent and selective Chk1 inhibitors: an improved synthesis, kinome profiling, structure-activity relationships, and preliminary pharmacokinetics. [electronic resource] - Bioorganic & medicinal chemistry letters Dec 2007 - 6593-601 p. digital
Publication Type: Comparative Study; Journal Article
1464-3405
10.1016/j.bmcl.2007.09.063 doi
Animals
Catalysis
Checkpoint Kinase 1
HeLa Cells
Humans
Macrocyclic Compounds--chemical synthesis
Mice
Protein Kinase Inhibitors--chemical synthesis
Protein Kinases--pharmacokinetics
Structure-Activity Relationship
Urea--chemical synthesis
Macrocyclic ureas as potent and selective Chk1 inhibitors: an improved synthesis, kinome profiling, structure-activity relationships, and preliminary pharmacokinetics. [electronic resource] - Bioorganic & medicinal chemistry letters Dec 2007 - 6593-601 p. digital
Publication Type: Comparative Study; Journal Article
1464-3405
10.1016/j.bmcl.2007.09.063 doi
Animals
Catalysis
Checkpoint Kinase 1
HeLa Cells
Humans
Macrocyclic Compounds--chemical synthesis
Mice
Protein Kinase Inhibitors--chemical synthesis
Protein Kinases--pharmacokinetics
Structure-Activity Relationship
Urea--chemical synthesis