Lead contamination results in late and slowly repairable DNA double-strand breaks and impacts upon the ATM-dependent signaling pathways.

Gastaldo, Jérôme

Lead contamination results in late and slowly repairable DNA double-strand breaks and impacts upon the ATM-dependent signaling pathways. [electronic resource] - Toxicology letters Sep 2007 - 201-14 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0378-4274

10.1016/j.toxlet.2007.08.003 doi


Ataxia Telangiectasia Mutated Proteins
Cell Cycle Proteins--metabolism
Cell Line
DNA Breaks, Double-Stranded
DNA Repair--drug effects
DNA-Activated Protein Kinase--metabolism
DNA-Binding Proteins--metabolism
Dose-Response Relationship, Drug
Endothelial Cells--drug effects
G2 Phase--drug effects
Histones--metabolism
Humans
Lead--toxicity
MRE11 Homologue Protein
Mutagens--toxicity
Nitrates--toxicity
Oxidative Stress--drug effects
Protein Serine-Threonine Kinases--metabolism
Rad51 Recombinase--metabolism
Recombination, Genetic--drug effects
S Phase--drug effects
Signal Transduction--drug effects
Time Factors
Tumor Suppressor Proteins--metabolism
X-Rays